Drugs A - Z

Hydrazine sulfate (HS)

treats Cachexia and Cancer treatment

Generic Name: Hydrazine sulfate

Category

Herbs & Supplements

Synonyms

2,4-dinitro-phenylhydrazine, alpha-methyldopa-hydrazine, beta-phenylisopropylhydrazine, carbidopa, diamide, diamine, dimethylhydrazine, hydrazine, hydrazine monosulphate, hydrazine sulphate, hydrazinium sulphate, hydrazonium sulphate, idrazina solfato (Italian), Sehydrin®.

Background

Cachexia is defined as physical wasting with loss of weight and muscle mass caused by disease. Patients with advanced cancer, AIDS, and some other major chronic progressive diseases may appear cachectic. Anorexia (lack of appetite) and cachexia often occur together. Cachexia can occur in people who are eating enough, but who cannot absorb the nutrients. Cachexia is not the same as starvation. A healthy person's body can adjust to starvation by slowing down its use of nutrients, but in cachectic patients, the body does not make this adjustment.

Hydrazine is an industrial chemical marketed as having the potential to repress weight loss and cachexia associated with cancer and to improve general appetite status. However, in large randomized controlled trials, hydrazine has not been proven effective for improving appetite, reducing weight loss, or improving survival in adults with small cell lung cancer (when used as adjuvant therapy) or metastatic colorectal cancer (when used alone).

Hydrazine sulfate causes liver damage in rodents. It is associated with nausea and vomiting, fatigue, sensory and motor neuropathies, and a significantly reduced quality of life in cancer patients. It is currently being investigated as a potential treatment for endotoxin-mediated shock. Hydrazine sulfate has demonstrated significant mutagenic and carcinogenic potential in animal studies.

Hydrazine has not been well evaluated for safety or toxicity during pregnancy, lactation, or childhood.

Other applications of hydrazine include: corrosion inhibitor, herbicide and pesticide component, laboratory reagent, refining rare metals, soldering flux for light metals, silvering of mirrors, and rocket fuel.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Cachexia (cancer related): The results of multiple clinical studies for the use of hydrazine sulfate in cancer-related cachexia are conflicting. The use of hydrazine sulfate cannot be fully recommended due to the lack well-designed studies and potential risks. More established therapies are recommended at this time.
Grade: C

Cancer treatment: The National Cancer Institute (NCI) sponsored studies of hydrazine sulfate that claimed efficacy in improving survival for some patients with advanced cancer. Trial results found that hydrazine sulfate did not prolong survival for cancer patients. The U.S. Food and Drug Administration (FDA) has received requests from individual physicians for approval to use hydrazine sulfate on a case-by-case "compassionate use" basis on the chance that patients with no other available effective therapy might benefit. The overall controversy in the use of hydrazine sulfate is ongoing, and relevance to clinical practice is unknown. The use of hydrazine sulfate needs to be evaluated further before any recommendations can be made. Side effects have been reported.
Grade: C

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Analytical tests for blood, anorexia, antidepressant, antioxidant, biocide for molds and fungi (onychomycosis), chemotherapy, impaired glucose tolerance, multi-drug resistance (tachyphylaxis), normalizing laboratory indices, nutritional support (improving caloric intake), pain, Parkinson's disease, sickle-cell anemia, tuberculosis, weight loss (prevention).
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