Drugs A - Z

Gymnema (Gymnema sylvestre R. Br.)

treats High cholesterol, Weight loss, and Diabetes

Generic Name: Gymnema sylvestre

Category

Herbs & Supplements

Synonyms

Asclepiadaceae (family), Asclepias geminata roxb., Gemnema melicida, GS4 (water soluble extract of the leaves), gur-mar, gurmar, gurmarbooti, Gymnema inodum, Gymnema montanum, Gymnema sylvestre, kogilam, madhunashini, mangala gymnema, merasingi, meshashringi, meshavalli, miracle plant, periploca of the woods, Periploca sylvestris, podapatri, Proβeta®, ram's horn, small Indian ipecac, sarkaraikolli, shardunika, sirukurinja, vishani.

Background

Preliminary human evidence suggests that gymnema may be effective in the management of blood sugar levels in type 1 and type 2 diabetes, as an adjunct to conventional drug therapy, for up to 20 months. Gymnema appears to lower serum glucose and glycosylated hemoglobin (HbA1c) levels following chronic use, but may not have significant acute effects. High-quality human trials are lacking in this area. Some of the available research has been conducted by authors affiliated with manufacturers of gymnema products.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Diabetes: Preliminary human research reports that gymnema may be beneficial in patients with type 1 or type 2 diabetes when it is added to diabetes drugs being taken by mouth or to insulin. Further studies of dosing, safety, and effectiveness are needed before a strong recommendation can be made.
Grade: B

High cholesterol: Preliminary research in people with type 2 diabetes reports decreased cholesterol and triglyceride levels. Better evidence is needed before a clear conclusion can be made.
Grade: C

Weight loss: Gymnema sylvestre extract (GSE) has been shown to be effective for weight loss when used in combination with other products. The effects of gymnema are difficult to determine, and additional high-quality trials using gymnema alone are needed to confirm these results.
Grade: C

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Allergy, antimicrobial, antioxidant, aphrodisiac, cancer, cardiovascular disease, constipation, cough, dental caries, digestive stimulant, diuresis, gout, high blood pressure, laxative, liver disease, liver protection, malaria, metabolic disorders, rheumatoid arthritis, snake venom antidote, stomach ailments, uterine stimulant, viral infection.

Dosing

Adults (18 years and older)

200 milligrams of extract GS4 taken by mouth twice daily or 2 milliliters of an aqueous decoction (10 grams of shade-dried powdered leaves per 100 milliliters) three times daily have been studied.

The manufacturer PharmaTerra recommends the dose for their product Proβeta® (GS4) to be two 250 milligram capsules taken twice daily at mealtimes (for adults weighing more than 100 pounds) or one 250 milligram capsule taken twice daily at mealtimes (for adults weighing less than 100 pounds).

Children (younger than 18 years)

There is not enough scientific evidence to safely recommend gymnema for use in children.

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