Drugs A - Z
Generic Name: amylase
CategoryHerbs & Supplements
AAI, alphaAI-1, alphaAI-2, arcelin-5, bean amylase inhibitors, Calorex, Fabaceae (family), Phase 2®, Phase 2 Starch Neutralizer®, phaseolamin, Phaseolus vulgaris extract, starch blockers, Starchex, wheat amylase inhibitor, wheat proteinaceous alpha-amylase inhibitors (alpha-AIs), white kidney bean extract.
Amylase is an enzyme that breaks down carbohydrates or starches in the body. Because of their purported ability to prevent starch breakdown and absorption, alpha amylase inhibitors have been used for weight loss. At this time, commercially available amylase inhibitors are extracted from wheat or white kidney bean (Phaseolus vulgaris).
In humans, amylase inhibitors have been shown to decrease intestinal absorption of carbohydrates by reducing intestinal amylase activity. However, there are few high-quality human studies that support the use of amylase inhibitors for any indication.
EvidenceDISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Amylase inhibitors have been shown to decrease levels of blood glucose. Large, well-designed studies are needed before a firm recommendation can be made.
Preliminary studies have shown that taking an amylase inhibitor with meals may lead to weight loss. However, well-designed clinical studies are needed in this area.
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antibacterial, antifungal, insecticide.
Adults (18 years and older)
Various doses of amylase inhibitors have been studied but no dose has been proven effective. Typically, 1,500-6,000 milligrams amylase inhibitors has been used before meals.
For diabetes, 4-6 grams has been used for up to seven days. For weight loss, a dose of 3,000 amylase inhibitor units from Phase 2® (white kidney bean derived amylase inhibitor) has been used daily for 30 days. A dose of 1,500 milligrams Phase 2® has been used twice daily for eight weeks without effect.
Children (under 18 years old)
There is no proven safe or effective dose for amylase inhibitors in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with known allergy or sensitivity to amylase inhibitors or sources of amylase inhibitors, such as wheat or legumes.
Side Effects and Warnings
Amylase inhibitors may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood glucose levels may need to be monitored by a qualified healthcare professional and medication adjustments may be necessary.
Amylase inhibitors should be used with caution in individuals with gastrointestinal disorders, kidney disorders, or liver problems. When used in combination with other weight loss agents, amylase inhibitors may have additive effects.
Pregnancy and Breastfeeding
Interactions with Drugs
Amylase inhibitors may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or injection should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.
When taken with other weight loss agents, amylase inhibitors may have additive effects.
Interactions with Herbs and Dietary Supplements
Amylase inhibitors may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need to be adjusted.
When taken with other weight loss agents, including Garcinia cambogia, inulin, and rosmarinic acid, amylase inhibitors may have additive effects. Amylase inhibitors may also interact with guar.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Julie Conquer, PhD (RGB Consulting); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Tera Stock, PharmD (Massachusetts College of Pharmacy and Health Sciences); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94(2):387-394.
Boivin M, Zinsmeister AR, Go VL, et al. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin.Proc. 1987;62(4):249-255.
Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am.J Gastroenterol. 1987;82(8):718-722.
Celleno L, Tolaini MV, D'Amore A, et al. A Dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. Int.J Med.Sci. 2007;4(1):45-52.
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Chokshi D. Toxicity studies of Blockal, a dietary supplement containing Phase 2 Starch Neutralizer (Phase 2), a standardized extract of the common white kidney bean (Phaseolus vulgaris). Int.J Toxicol. 2006;25(5):361-371.
Choudhury A, Maeda K, Murayama R, et al. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111(5):1313-1320.
Lankisch M, Layer P, Rizza RA, et al. Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans. Pancreas 1998;17(2):176-181.
Layer P, Zinsmeister AR, DiMagno EP. Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans. Gastroenterology 1986;91(1):41-48.
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Rekha MR, Padmaja G. Alpha-amylase inhibitor changes during processing of sweet potato and taro tubers. Plant Foods Hum.Nutr. 2002;57(3-4):285-294.
Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int.Med.Res. 2000;28(5):229-233.
Udani J, Hardy M, Madsen DC. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Altern.Med.Rev. 2004;9(1):63-69.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.