Drugs A - Z

Amylase inhibitors

treats Obesity/weight loss and Diabetes

Generic Name: amylase

Category

Herbs & Supplements

Synonyms

AAI, alphaAI-1, alphaAI-2, arcelin-5, bean amylase inhibitors, Calorex, Fabaceae (family), Phase 2®, Phase 2 Starch Neutralizer®, phaseolamin, Phaseolus vulgaris extract, starch blockers, Starchex, wheat amylase inhibitor, wheat proteinaceous alpha-amylase inhibitors (alpha-AIs), white kidney bean extract.

Background

Amylase is an enzyme that breaks down carbohydrates or starches in the body. Because of their purported ability to prevent starch breakdown and absorption, alpha amylase inhibitors have been used for weight loss. At this time, commercially available amylase inhibitors are extracted from wheat or white kidney bean (Phaseolus vulgaris).

In humans, amylase inhibitors have been shown to decrease intestinal absorption of carbohydrates by reducing intestinal amylase activity. However, there are few high-quality human studies that support the use of amylase inhibitors for any indication.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Diabetes: Amylase inhibitors have been shown to decrease levels of blood glucose. Large, well-designed studies are needed before a firm recommendation can be made.
Grade: C

Obesity/weight loss: Preliminary studies have shown that taking an amylase inhibitor with meals may lead to weight loss. However, well-designed clinical studies are needed in this area.
Grade: C

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antibacterial, antifungal, insecticide.

Dosing

Adults (18 years and older)

Various doses of amylase inhibitors have been studied but no dose has been proven effective. Typically, 1,500-6,000 milligrams amylase inhibitors has been used before meals.

For diabetes, 4-6 grams has been used for up to seven days. For weight loss, a dose of 3,000 amylase inhibitor units from Phase 2® (white kidney bean derived amylase inhibitor) has been used daily for 30 days. A dose of 1,500 milligrams Phase 2® has been used twice daily for eight weeks without effect.

Children (under 18 years old)

There is no proven safe or effective dose for amylase inhibitors in children.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with known allergy or sensitivity to amylase inhibitors or sources of amylase inhibitors, such as wheat or legumes.

Side Effects and Warnings

Amylase inhibitors may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood glucose levels may need to be monitored by a qualified healthcare professional and medication adjustments may be necessary.

Amylase inhibitors should be used with caution in individuals with gastrointestinal disorders, kidney disorders, or liver problems. When used in combination with other weight loss agents, amylase inhibitors may have additive effects.

Pregnancy and Breastfeeding

Amylase inhibitors are not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

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