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Drug Notebook

Generic Name: ziprasidone

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An atypical antipsychotic - treats Schizophrenia and Bipolar Disorder

FDA Alerts

Increased Mortality in Geriatric Patients

Substantially higher mortality rate (4.5%) in geriatric patients with dementia-related psychosis† receiving atypical antipsychotic agents (e.g., aripiprazole, olanzapine, quetiapine, risperidone) compared with those receiving placebo (2.6%).
Most fatalities resulted from cardiac-related events (e.g., heart failure, sudden death) or infections (mostly pneumonia).
Atypical antipsychotics are not approved for the treatment of dementia-related psychosis. (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis under Cautions.)

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ziprasidone

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What other drugs will affect ziprasidone?

Before taking ziprasidone, tell your doctor if you are using any of the following drugs:

a diuretic (water pill), blood pressure medicine, or heart rhythm medicine;
carbamazepine (Carbatrol, Tegretol);
cisapride (Propulsid);
haloperidol (Haldol);
narcotic pain medication;
medicines used to treat Parkinson's Disease such as levodopa (Dopar, Larodopa, Sinemet, Atamet, others); or
antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), ketoconazole (Nizoral), or telithromycin (Ketek).

This list is not complete and there may be other drugs that can interact with ziprasidone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about ziprasidone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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·As a Drug

Bipolar Disorder (Manic Depression)