What is the most important information I should know about valproic acid?
In rare cases, valproic acid has caused life-threatening liver failure, especially in children
younger than 2 years old. Children of this age may be at even greater risk for liver problems if
they use more than one seizure medication, if they have a metabolic disorder, or if they have a
brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease,
multiple sclerosis, or a brain injury or infection).
Valproic acid has also caused rare cases of life-threatening pancreatitis (inflammation of
the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have
been taking valproic acid for several years.
Seek emergency medical attention if the person taking this medicine has nausea,
vomiting,
stomach pain, or loss of appetite, low fever,
dark urine,
clay-colored stools, or
jaundice
(
yellowing of the skin or eyes). These symptoms may be early signs of liver damage. Some of
these symptoms may also be early signs of pancreatitis.
Valproic acid can cause birth defects. Do not use this medication
without your doctor's consent if you are pregnant. It could cause harm to the unborn baby. Use
an effective form of birth control, and tell your doctor if you become pregnant during treatment.
You may have thoughts about suicide while taking this medication. Your doctor will
need to check you at regular visits. Do not miss any scheduled appointments.
Call your doctor at once if you have any new or worsening symptoms such as: mood
or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive
(mentally or physically), or have thoughts about suicide or hurting yourself.
What is valproic acid?
Valproic acid affects chemicals in the body that may be involved in causing seizures.
Valproic acid is used to treat various types of seizure disorders. Valproic acid is
sometimes used together with other seizure medications.
Valproic acid may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking valproic acid?
In rare cases, valproic acid has caused life-threatening liver failure, especially in children
younger than 2 years old. Children of this age may be at even greater risk for liver problems if
they use more than one seizure medication, if they have a metabolic disorder, or if they have a
brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease,
multiple sclerosis, or a brain injury or infection).
Valproic acid has also caused rare cases of life-threatening pancreatitis (inflammation of
the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have
been taking valproic acid for several years. Do not take valproic acid if you have liver disease or
a urea cycle disorder.
Before taking valproic acid, tell your doctor if you have:
If you have any of these conditions, you may not be able to use
valproic acid, or you may need a dosage adjustment or special tests during treatment.
You may have thoughts about suicide while taking this medication. Tell your doctor if
you have new or worsening depression or suicidal thoughts during the first several months of
treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or
symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled
appointments.
FDA pregnancy category D. This medication can cause harm to an unborn baby. Do
not use valproic acid without your doctor's consent if you are pregnant. Tell your doctor if you
become pregnant during treatment. Valproic acid can cause birth defects.
Use an effective form of birth control while you are using this medication.
Valproic acid passes into breast milk and could harm a nursing infant. Do not take
valproic acid without telling your doctor if you are breast-feeding a baby.
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