Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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trifluoperazine
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(trye floo oh PER a zeen)

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a trifluoperazine overdose include uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature.

What should I avoid while taking trifluoperazine?

Use caution when driving, operating machinery, or performing other hazardous activities. Trifluoperazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking trifluoperazine. Avoid prolonged exposure to sunlight. Trifluoperazine may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.

What are the possible side effects of trifluoperazine?

If you experience any of the following serious side effects, stop taking trifluoperazine and seek emergency medical treatment:

Other, less serious side effects may be more likely to occur. Continue to take trifluoperazine and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect trifluoperazine?

Trifluoperazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if trifluoperazine is taken with alcohol or any of these medications. Talk to your doctor before taking trifluoperazine in combination with alcohol or any other prescription or over-the-counter medicines.

Trifluoperazine also interacts with medications other than the ones listed here. Before taking trifluoperazine, tell your doctor about all other prescription and over-the-counter medicines you are taking, including herbal products. During treatment, do not start taking any new drug without first talking to your doctor.

Where can I get more information?

Your pharmacist has additional information about trifluoperazine written for health professionals that you may read.

What does my medication look like?

Trifluoperazine is available with a prescription under the brand name Stelazine. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Stelazine 1 mg--round, blue, coated tablets

  • Stelazine 2 mg--round, blue, coated tablets

  • Stelazine 5 mg--round, blue, coated tablets

  • Stelazine 10 mg--round, blue, coated tablets

  • Stelazine Concentrate10 mg/ 1 mL--clear, yellow, banana-vanilla-flavored liquid

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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