• fever, breathing problems, weight gain, swelling of your hands or feet;

• sudden and severe pain behind your eyes, with nausea, vomiting, and vision problems;

• black, bloody, or tarry stools; or

• vomit that looks like blood or coffee grounds.

Less serious side effects may include:

• feeling tired or weak;

• headache;

• fever;

• dry skin, mouth, or nose;

• bone pain;

• nausea and vomiting;

• rash or itching;

• white patches or sores inside your mouth or on your lips;

• increased sweating;

• vision problems; or

• hair loss or skin changes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect tretinoin?

Before taking tretinoin, tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• cyclosporine (Neoral, Sandimmune, Gengraf);

• troleandomycin (Tao);

• rifampin (Rifadin, Rimactane, Rifater);

• phenobarbital (Luminal);

• fluoxetine (Prozac), fluvoxamine (Luvox);

• steroids (prednisone and others);

• itraconazole (Sporanox), ketoconazole (Nizoral);

• clarithromycin (Biaxin), erythromycin (Erythrocin, Ery-Tab, E.E.S.);

• a tetracycline antibiotic such as minocycline (Dynocin, Minocin, Vectrin), doxycycline (Doryx, Vibramycin), demeclocycline (Declomycin);

• amiodarone (Cordarone), mibefradil (Posicor), diltiazem (Tiazac, Cardizem), verapamil (Covera, Calan); or

• HIV medicines such as indinavir (Crixivan), saquinavir (Invirase), ritonavir (Norvir), saquinavir (Invirase), or nelfinavir (Viracept).

This list is not complete and there may be other drugs that can interact with tretinoin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about tretinoin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.