Drug Notebook

FDA Alerts

  • Possible life-threatening adverse hematologic effects (e.g., neutropenia and/or agranulocytosis, thrombotic thrombocytopenic purpura [TTP], aplastic anemia). Careful monitoring of hematologic status required. (See Hematologic Toxicity under Cautions.)

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ticlopidine
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(tye KLOE pih deen)

How should I take ticlopidine?

Take ticlopidine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take ticlopidine with food or just after eating to lessen stomach upset.

Your doctor will need to monitor your blood with blood tests before starting treatment with ticlopidine and every 2 weeks for the first 3 months of treatment. If your treatment with ticlopidine is stopped within the first three months of treatment, you will still need a blood test two weeks after stopping the medication.

Store ticlopidine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a ticlopidine overdose are unknown but might include vomiting, difficulty breathing, blood in the vomit or stool, seizures, and loss of coordination.

What should I avoid while taking ticlopidine?

Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, others), naproxen (Aleve, Anaprox, Naprosyn, others), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), or other nonsteroidal anti-inflammatory drugs (NSAIDs) without first talking to your doctor.

Tell your doctor and dentist that you are taking this medication before undergoing any surgical procedures.

What are the possible side effects of ticlopidine?

If you experience any of the following serious side effects, stop taking ticlopidine and seek emergency medical attention or notify your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • bloody or black vomit or stools;

  • unusual, prolonged, or severe bleeding or bruising;

  • fever, chills, a sore throat, or other signs of infection;

  • a rash (including pinpoint dots on the skin);

  • yellow skin or eyes;

  • abdominal pain;

  • dark-yellow urine;

  • light-colored stools;

  • pale skin;

  • weakness on a side of the body;

  • severe headache, confusion, or dizziness;

  • easy bruising; or

  • a bleeding nose.

Other, less serious side effects may also occur. Continue to take ticlopidine and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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