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What are the possible side effects of sulfinpyrazone?

Stop taking sulfinpyrazone and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Heartburn, nausea, and upset stomach are the most common side effects of sulfinpyrazone therapy. Take each dose with food, milk, or an antacid to decrease these side effects.

Contact your doctor as soon as possible if you experience an acute attack of gouty arthritis.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect sulfinpyrazone?

Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan's), choline and magnesium salicylate (Trilisate), or other aspirin-like products unless your doctor approves. These products decrease the effects of sulfinpyrazone. Taking one aspirin a day to reduce the risk of a heart attack is usually acceptable.

The combination of sulfinpyrazone and acetaminophen (in Tylenol and many other products) can be damaging to your liver. Do not take products that contain acetaminophen unless your doctor approves.

Sulfinpyrazone may increase the effects of the following medicines:

• warfarin (Coumadin), which could lead to bleeding; and

• tolbutamide (Orinase), which could lead to low blood sugar levels.

You may need lower doses of these drugs.

Sulfinpyrazone may decrease the effects of other medicines:

• theophylline (Theo-Dur, Theochron, Theolair, Elixophylline, others), which could lead to worsening asthma or chronic obstructive pulmonary disease (COPD); and

• verapamil (Verelan, Calan, Isoptin), which could lead to worsening heart problems such as high blood pressure or an irregular heartbeat.

You may need higher doses of these drugs.

Niacin (Nicolar, Nicobid, others) may decrease the effects of sulfinpyrazone. A dose adjustment may be necessary.

Drugs other than those listed here may also interact with sulfinpyrazone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has more information about sulfinpyrazone written for health professionals that you may read.

What does my medication look like?

Sulfinpyrazone is available with a prescription generically and under the brand name Anturane. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Anturane 100 mg--white, round, scored tablets

• Anturane 200 mg--green capsules

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.