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Generic Name: rituximab

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An antirheumatic - treats non-Hodgkin's Lymphoma and Rheumatoid Arthritis

FDA Alerts

Fatal Infusion-related Reactions

Death has occurred within 24 hours of administration following the occurrence of severe infusion-related effects (i.e., hypoxia, pulmonary infiltrates, acute respiratory distress syndrome, MI, VF, and/or cardiogenic shock).
Approximately 80% of fatal reactions have occurred with the first dose.
If severe infusion-related effects occur, discontinue rituximab infusion and institute appropriate treatment. (See Infusion-related Effects under Cautions.)

Tumor Lysis Syndrome

Acute renal failure requiring dialysis (sometimes fatal) reported in patients with non-Hodgkin’s lymphoma who experience tumor lysis syndrome. (See Tumor Lysis Syndrome under Cautions.)

Severe Mucocutaneous Reactions

Severe, sometimes fatal, mucocutaneous reactions reported. (See Mucocutaneous Reactions under Cautions.)

Progressive Multifocal Leukoencephalopathy (PML)

JC virus infection resulting in PML and death reported. (See Progressive Multifocal Leukoencephalopathy [PML] under Cautions.)

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rituximab

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(ri TUK si mab)

What other drugs will affect rituximab?

Before receiving rituximab, tell your doctor if you are also being treated with any of the following drugs:

cisplatin (Platinol);
adalimumab (Humira);
azathioprine (Imuran);
cyclosporine (Gengraf, Neoral, Sandimmune);
etanercept (Enbrel);
infliximab (Remicade);
leflunomide (Arava);
minocycline (Dynacin, Minocin, Vectrin);
sulfasalazine (Azulfidine);
blood pressure medications;
gold salts such as auranofin (Ridaura), aurothioglucose (Solganal); or
medication to treat malaria, such as chloroquine (Aralen) or hydroxychloroquine (Plaquenil, Quineprox).

This is not a complete list and there may be other drugs that can affect rituximab. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about rituximab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Related Learning
Centers

·As a Drug

Chronic Lymphocytic Leukemia (CLL)

Lymphomas

Non-hodgkin's Lymphoma

Thrombotic Thrombocytopenic Purpura (TTP)

Waldenstrom's Disease

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