• sudden headache, numbness or weakness (especially on one side of the body), shortness of breath, or problems with vision, speech, or balance;

• chest pain or heavy feeling, pain spreading to the arm or shoulder;

• pain or swelling in one or both legs;

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• swelling in your hands, ankles, or feet;

• fever, chills, body aches, flu symptoms;

• a breast lump; or

• symptoms of depression (sleep problems, weakness, mood changes).

Less serious side effects may include:

• mild nausea, vomiting, bloating, stomach cramps;

• diarrhea, constipation, bloating;

• dizziness, drowsiness, tired feeling;

• pain in your vaginal or rectal area;

• pain during intercourse;

• loss of interest in sex;

• breast pain, swelling, or tenderness;

• joint or muscle pain;

• increased night-time urination; or

• vaginal itching, burning, or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect progesterone vaginal?

There may be other drugs that can interact with progesterone vaginal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about progesterone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.