• Basic Info
• Top Questions
• Clinical Info
• Interactions

What other drugs will affect prochlorperazine?

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• antacids (take antacids at least 2 hours before or 2 hours after taking a dose of prochlorperazine; otherwise they will decrease the effectiveness of your medication);

• alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; or seizure medications. (these drugs will increase the side of effects of prochlorperazine, especially drowsiness and dizziness);

• blood pressure medications such as propranolol (Inderal), methyldopa (Aldomet), and clonidine (Catapres) (these medicines may cause dizziness and fainting if used with prochlorperazine);

• anticoagulants such as warfarin (Coumadin) (these medicines may have decreased effects, which could lead to blood clotting); and

• phenytoin (Dilantin) (prochlorperazine may increase the effects of phenytoin and lead to side effects; you may need a lower dose of phenytoin).

Drugs other than those listed here may also interact with prochlorperazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about prochlorperazine written for health professionals that you may read.

What does my medication look like?

Prochlorperazine is available with a prescription under the brand name Compazine. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Compazine 5 mg--round, yellow, film-coated tablets

• Compazine 10 mg--round, yellow, film-coated tablets

• Compazine Spansule 10 mg--black/clear capsules with yellow pellets

• Compazine Spansule 15 mg--black/clear capsules with yellow pellets

• Compazine Syrup 5 mg/5 mL--clear, orange-yellow, fruit-flavored liquid

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.