Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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prochlorperazine
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(pro klor PER a zeen)

What happens if I miss a dose?

If you are taking prochlorperazine as needed for nausea and vomiting, take the missed dose as soon as possible, if it is needed, and then wait at least 4 hours before taking another dose.

If you are taking prochlorperazine once a day for any other condition, take the missed dose as soon as you remember, then go back to your regular schedule the next day. If you do not remember until the next day, skip the dose you missed and take only the dose regularly scheduled for that day. Do not take a double dose of this medication.

If you are taking prochlorperazine several times a day for a condition other than nausea and vomiting, take the missed dose within 1 hour of its regular time. If more than 1 hour has passed, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose.

What happens if I overdose?

Seek emergency medical treatment.

Symptoms of a prochlorperazine overdose include uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, deep sleep, irregular heartbeats, and high or low body temperature.

What should I avoid while taking prochlorperazine?

Use caution when driving, operating machinery, or performing other hazardous activities. Prochlorperazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking prochlorperazine. Avoid prolonged exposure to sunlight. Prochlorperazine may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What are the possible side effects of prochlorperazine?

If you experience any of the following serious side effects, stop taking prochlorperazine and seek emergency medical treatment:

Other, less serious side effects may be more likely to occur. Continue to take prochlorperazine and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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