• worsening gout symptoms;

• severe pain in your side or lower back;

• blood in your urine;

• swelling, especially in your face, stomach, ankles, or feet; or

• pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Less serious side effects may include:

• urinating more than usual;

• mild nausea, vomiting, loss of appetite;

• headache, dizziness;

• sore gums;

• mild itching or skin rash;

• hair loss; or

• warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect probenecid?

Many drugs can interact with probenecid. Below is just a partial list. Tell your doctor if you are using:

• lorazepam (Ativan);

• methotrexate (Rheumatrex, Trexall);

• rifampin (Rifadin, Rifamate, Rimactane);

• diabetes medication you take by mouth;

• an NSAID (nonsteroidal anti-inflammatory drug) such as ketoprofen (Orudis, Oruvail), indomethacin (Indocin), meclofenamate (Meclomen), or naproxen (Aleve, Anaprox, Naprosyn);

• salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others; or

• a sulfa drug such as Bactrim, Cotrim, Septra, SMX/TMP, and others.

This list is not complete and there may be other drugs that can interact with probenecid. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about probenecid.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.