Drug Notebook

FDA Alerts

  • Penicillin G benzathine (Bicillin® C-R, Bicillin® C-R 900/300), penicillin G procaine, and fixed combination containing penicillin G benzathine and penicillin G procaine (Bicillin® L-A) are administered by deep IM injection only and should not be injected IV or admixed with other IV solutions.
  • Prior to administration of penicillin G benzathine, penicillin G procaine, or fixed combination of penicillin G benzathine and penicillin G procaine, carefully read the warnings, adverse reactions, and dosage and administration sections of the prescribing information.
  • Inadvertent IV administration of penicillin G benzathine has been associated with cardiorespiratory arrest and death.

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(pen i SILL in)

What is the most important information I should know about penicillin G potassium ?

Do not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceclor, Ceftin, Duricef, Keflex, Lorabid, Omnicef, Spectracef, and others. Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Penicillin G potassium will not treat a viral infection such as the common cold or flu.

After you have finished your treatment with penicillin G potassium, your doctor may want to do tests to make sure your infection has completely cleared up.

What is penicillin G potassium ?

Penicillin G potassium is an antibiotic that fights bacteria in your body.

Penicillin G potassium is used to treat many different types of severe infections, including strep and staph infections, diphtheria, meningitis, gonorrhea, and syphilis.

Penicillin G potassium is also used to prevent infections of the heart valves in people with certain heart conditions who need to have dental work or surgery.

Penicillin G potassium may also be used for other purposes not listed in this medication guide.

What should I discuss with my health care provider before using penicillin G potassium ?

Do not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceclor, Ceftin, Duricef, Keflex, Lorabid, Omnicef, Spectracef, and others.

Before using this medication, tell your doctor if you are allergic to any foods or drugs, or if you have:

If you have any of these conditions, you may need a dose adjustment or special tests to safely use penicillin G potassium.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Penicillin G potassium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use penicillin G potassium ?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Penicillin G potassium is given as an injection into a muscle or vein. It may also be injected into the membrane surrounding the lungs. The medicine must be given slowly through an IV infusion, and can take up to 24 hours to complete.

Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Penicillin G potassium will not treat a viral infection such as the common cold or flu.

After you have finished your treatment with penicillin G potassium, your doctor may want to do tests to make sure your infection has completely cleared up.

Store the dry powder medicine at room temperature away from moisture and heat.
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