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What happens if I miss a dose?

If you miss a dose of pegvisomant, skip the missed dose and use only the next regularly scheduled dose the next day. Do not use a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention or contact your doctor immediately if an overdose of pegvisomant is suspected.

Symptoms of a pegvisomant overdose may include fatigue.

What should I avoid while taking pegvisomant?

There are no restrictions on food, beverages, or activity during treatment with pegvisomant unless otherwise directed by your healthcare provider.

What are the possible side effects of pegvisomant?

If you experience any of the following uncommon but serious side effects, stop taking pegvisomant and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or

• liver problems (may be detected by blood tests or symptoms such as yellowing of the skin or eyes, vomiting, abdominal pain, unusual fatigue, loss of appetite, itching, clay-colored stools, or dark urine).

Other, less serious side effects may be more likely to occur. Continue to take pegvisomant and talk to your doctor if you experience

• discomfort at the injection site;

• "flu-like" symptoms

• nausea or diarrhea;

• dizziness; or

• water retention or slight weight gain.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pegvisomant?

Before taking pegvisomant, tell your doctor if you are taking any of the following medicines:

• insulin;

• any medicine taken by mouth to treat diabetes such as glyburide (Diabeta, Glynase, Micronase), glipizide (Glucotrol), glimepiride (Amaryl), rosiglitazone (Avandia), pioglitazone (Actos), and others; or

• a narcotic pain or cough medication such as codeine (Tylenol #3, others), hydrocodone (Vicodin, Lorcet, others), oxycodone (Percocet, others), morphine (MS Contin, MSIR, OxyContin, others), fentanyl (Duragesic, others), and others.

You may not be able to take pegvisomant, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with pegvisomant. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

Your pharmacist has additional information about pegvisomant that you may read.

What does my medication look like?

Pegvisomant is available with a prescription under the brand name Somavert as an injectable formulation. Other brand or generic products may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.