Generic Name: oxaprozin

What is the most important information I should know about oxaprozin?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking oxaprozin. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What is oxaprozin?

Oxaprozin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Oxaprozin works by reducing hormones that cause inflammation and pain in the body.

Oxaprozin is used to treat pain or inflammation caused by arthritis.

Oxaprozin may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking oxaprozin?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Before taking oxaprozin, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot;

• heart disease, congestive heart failure, high blood pressure;

• a history of stomach ulcers or bleeding, bowel problems, diverticulosis;

• liver or kidney disease;

• asthma;

• polyps in your nose; or

• if you smoke.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Taking oxaprozin during the last 3 months of pregnancy may result in birth defects. Do not take oxaprozin during pregnancy unless your doctor has told you to. Oxaprozin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 6 years old without the advice of a doctor.

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