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What is the most important information I should know about naloxone?

Before using naloxone, tell your doctor if you are using any narcotic pain medicines. The pain-relieving effects of any narcotic medications you use will be reversed if you use them during your treatment with naloxone. Withdrawal symptoms could also occur, such as body aches, diarrhea, increased heart rate, fever, sweating, nausea or vomiting, irritability, trembling, weakness, and increased blood pressure. Your doctor may want to observe you after using naloxone to watch for side effects.

Naloxone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol while taking naloxone. Alcohol may increase dizziness caused by naloxone.

What is naloxone?

Naloxone is an special narcotic drug that reverses the effects of other narcotic medicines.

Naloxone is used to reverse the effects of narcotic drugs used during surgery or to treat pain. Naloxone may also be used to treat narcotic drug overdose or to diagnose narcotic drug addiction.

Naloxone may also be used for other purposes not listed in this medication guide.

What should I discuss with my health care provider before using naloxone?

You should not use this medication if you are allergic to naloxone.

Before using naloxone, tell your doctor if you are allergic to any drugs, or if you have:

• a brain tumor or head injury;

• seizures;

• heart disease or a heart rhythm disorder; or

• a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use naloxone.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether naloxone passes into breast milk or if it could harm a nursing baby. Do not use naloxone without telling your doctor if you are breast-feeding a baby.

How should I use naloxone?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Naloxone is given as an injection under the skin, into a muscle, or into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Do not draw your naloxone dose into a syringe until you are ready to give yourself an injection. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Store this medication at room temperature away from heat and moisture.

What happens if I miss a dose?

Contact your healthcare provider if you miss a dose of naloxone.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include seizure (convulsions), feeling light-headed, or fainting.

What should I avoid while using naloxone?

Naloxone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol while taking naloxone. Alcohol may increase dizziness caused by naloxone.