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Generic Name: leflunomide

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An antirheumatic - treats Rheumatoid Arthritis

FDA Alerts

Contraindicated in pregnant women and women of childbearing potential who are not using a reliable form of contraception. (See Fetal/Neonatal Morbidity and Mortality and also Contraindications under Cautions.)
Pregnancy must be excluded prior to initiation of therapy.
Pregnancy must be avoided while the woman is receiving leflunomide and prior to completion of the drug elimination procedure following discontinuance of the drug. (See Drug Elimination Procedures Following Leflunomide Discontinuance under Dosage and Administration.)

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Arava
ZBO 20 mg
Leflunomide
174 / 93 20 mg	20 / B352 20 mg	10 / b 351 10 mg	173 / 93 10 mg

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leflunomide

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(le FLOO noe mide)

What other drugs will affect leflunomide?

Before taking leflunomide, tell your doctor if you are taking cholestyramine (Questran, Prevalite, LoCHOLEST) or rifampin (Rifadin, Rimactane).

Also tell your doctor if you are using medications that can weaken your immune system, such as:

methotrexate (Rheumatrex);
cyclosporine (Neoral, Sandimmune, Gengraf);
sirolimus (Rapamune), tacrolimus (Prograf);
basiliximab (Simulect), efalizumab (Raptiva), muromonab-CD3 (Orthoclone);
mycophenolate mofetil (CellCept); or
azathioprine (Imuran), leflunomide (Arava), etanercept (Enbrel).

This list is not complete and there may be other drugs that can interact with leflunomide. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about leflunomide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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