• dizziness, fainting, fast or pounding heartbeat;

• easy bruising or bleeding, unusual weakness;

• numbness or tingly feeling;

• severe depression, confusion, or thoughts of hurting yourself; or

• nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• mild nausea, vomiting, or stomach pain;

• mild itching or skin rash;

• headache;

• dizziness;

• breast swelling; or

• impotence or loss of interest in sex.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect ketoconazole?

Many drugs can interact with ketoconazole. Below is just a partial list. Tell your doctor if you are using:

• acetaminophen (Tylenol);

• cyclosporine (Gengraf, Sandimmune, Neoral);

• digoxin (digitalis, Lanoxin);

• tacrolimus ((Prograf);

• loratadine (Alavert, Claritin, Tavist ND);

• methylprednisolone (Medrol);

• phenytoin (Dilantin);

• rifampin (Rifadin, Rifater, Rifamate, Rimactane);

• diabetes medication you take by mouth;

• a sedative such as midazolam (Versed);

• a blood thinner such as warfarin (Coumadin);

• cancer medications;

• birth control pills or hormone replacement therapy;

• methotrexate (Rheumatrex, Trexall);

• cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or

• medications to treat HIV or AIDS.

This list is not complete and there are many other drugs that can interact with ketoconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about ketoconazole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.