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• Interactions

What other drugs will affect itraconazole?

Many drugs can interact with itraconazole. Below is just a partial list. Tell your doctor if you are using:

• a blood thinner such as warfarin (Coumadin);

• cancer medications;

• cholesterol medications such as atorvastatin (Lipitor);

• cyclosporine (Gengraf, Sandimmune, Neoral);

• diabetes medication you take by mouth;

• digoxin (digitalis, Lanoxin);

• disopyramide (Norpace);

• fentanyl (Actiq, Duragesic);

• isoniazid (for treating tuberculosis);

• rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater, Rifamate), or rifapentine (Priftin);

• sirolimus (Rapamune) or tacrolimus (Prograf);

• an antibiotic such as clarithromycin (Biaxin), clotrimazole (Mycelex Troche), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), ketoconazole (Nizoral), telithromycin (Ketek), troleandomycin (Tao), or voriconazole (Vfend);

• an antidepressant such as nefazodone, paroxetine (Paxil), or sertraline (Zoloft);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);

• heart or blood pressure medications such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others;

• HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase, Fortovase), or ritonavir (Norvir);

• a sedative such as alprazolam (Xanax), diazepam (Valium); or

• seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and there are many other medicines that can interact with itraconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about itraconazole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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