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What other drugs will affect isoniazid and rifampin?

Before taking isoniazid and rifampin, tell your doctor if you are taking any of the following drugs:

• antacids;

• ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox);

• disulfiram (Antabuse);

• warfarin (Coumadin);

• carbamazepine (Tegretol);

• cycloserine (Seromycin);

• phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);

• meperidine (Demerol);

• benzodiazepines such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril).

• acetaminophen (Tylenol, others);

• blood thinners such as warfarin (Coumadin);

• barbiturates such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol);

• beta-blockers such as atenolol (Tenormin), propranolol (Inderal), and metoprolol (Lopressor);

• heart medicines such as digoxin (Lanoxin), disopyramide (Norpace), quinidine (Quinora, Quinidex, Cardioquin, others), mexiletine (Mexitil), tocainide (Tonocard), verapamil (Calan, Verelan, Isoptin), and enalapril (Vasotec);

• corticosteroids such as prednisone (Deltasone, Orasone, Meticorten), prednisolone (Delta Cortef, Prelone, others), methylprednisolone (Medrol), and betamethasone (Celestone);

• sulfonylureas such as glipizide (Glucotrol), glyburide (Micronase, Diabeta, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), and tolazamide (Tolinase);

• sulfa medicines such as sulfamethoxazole (Bactrim, Septra, Gantanol, Azo-Gantanol), and sulfisoxazole (Gantrisin, Azo-Gantrisin);

• the HIV and AIDS medicines delavirdine (Rescriptor), saquinavir (Invirase), ritonavir (Norvir), indinavir (Crixivan), nelfinavir (Viracept), and zidovudine (Retrovir);

• estrogens such as Premarin, Ogen, Estrace, Menest, Estratab, Ortho-Est, and others;

• oral birth control pills such as Triphasil, Ortho-Novum, Ortho-Cyclen, Ortho-Tri-Cyclen, Ovral, Lo/Ovral, Desogen, Nordette, Levora, Levlen, Tri-Levlen, Nelova, Norinyl, Brevicon, Ovcon, Loestrin, Demulen, and others;

• phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);

• theophylline (Theolair, Theo-Dur, Theochron, Theo-Bid, others);

• methadone (Dolophine);

• clofibrate (Atromid-S); or

• cyclosporine (Sandimmune, Neoral).

You may not be able to take isoniazid and rifampin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with isoniazid and rifampin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about isoniazid and rifampin written for health professionals that you may read.

What does my medication look like?

Isoniazid and rifampin is available with a prescription under the brand name Rifamate. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Rifamate 150 mg isoniazid and 300 mg rifampin--red capsules

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.