What is the most important information I should know about isoniazid/pyrazinamide/rifampin?
Take all of the isoniazid/pyrazinamide/rifampin that has been prescribed for you even
if you begin to feel better. Your symptoms may begin to improve before the infection is
completely treated.
Avoid alcohol while taking isoniazid/pyrazinamide/rifampin. Alcohol will increase
the risk of damage to your liver during treatment with this medication.
Call your doctor immediately if you experience a fever, chills, a sore throat, muscle and
bone pain, painful or swollen joints, a headache, excessive tiredness or weakness, numbness or
tingling in your hands or feet, loss of appetite, nausea and vomiting, yellowing of your skin or
eyes, darkening of your urine, unusual bleeding or bruising, a rash, or itching.
Take isoniazid/pyrazinamide/rifampin on an empty
stomach 1 hour before or 2 hours
after meals.
This medication may decrease the effectiveness of birth control pills. Talk to your
doctor about using another form of birth control during treatment.
What is isoniazid/pyrazinamide/rifampin?
Isoniazid, pyrazinamide, and rifampin are antibiotics. They prevent tuberculous bacteria
from multiplying in your body.
Isoniazid, pyrazinamide, and rifampin are used together to treat tuberculosis (TB).
Isoniazid/pyrazinamide/rifampin may also be used for purposes other than those listed in
this medication guide.
Who should not take isoniazid/pyrazinamide/rifampin?
Before taking this medication, tell your doctor if you have
You may not be able to take isoniazid/pyrazinamide/rifampin, or you
may require a lower dose or special monitoring during treatment if you have any of the
conditions listed above.
It is not known whether isoniazid/pyrazinamide/rifampin will harm an unborn baby.
Do not take this medication without first talking to your doctor if you are pregnant.
It is also not known whether isoniazid/pyrazinamide/rifampin will harm a nursing
baby. Do not take this medication without first talking to your doctor if you are breast-feeding a
baby.
How should I take isoniazid/pyrazinamide/rifampin?
Take isoniazid/pyrazinamide/rifampin exactly as directed by your doctor. However, if you
do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to
you.
Take each dose with a full glass (8 ounces) of water.
Take isoniazid/pyrazinamide/rifampin on an empty stomach 1 hour before or 2 hours
after a meal.
Take all of the isoniazid/pyrazinamide/rifampin that has been prescribed for you even
if you begin to feel better. Your symptoms may begin to improve before the infection is
completely treated.
Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet
daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.
Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next regularly
scheduled dose, skip the missed dose and take the next one as directed. Do not
take a double dose of this medication.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of an isoniazid/pyrazinamide/rifampin overdose include nausea, vomiting,
abdominal pain, tiredness, dizziness, slurring of speech, yellow skin or eyes, blurred vision,
visual hallucinations, seizures, coma, and death.
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