Drug Notebook

FDA Alerts

  • May cause potentially fatal arrhythmias. Should be administered only by skilled personnel in a setting in which proper equipment (e.g., cardiac monitors, intracardiac pacing, cardioverter/defibrillator) and therapy for sustained VT are available during and after drug administration. (See Arrythmogenic Effects under Cautions.)
  • Adequate anticoagulation recommended for patients with atrial fibrillation of more than 2–3 days’ duration.
  • Select patients carefully such that the expected benefits of conversion to sinus rhythm outweigh the immediate risks of ibutilide therapy. Use ibutilide when it is likely to offer an advantage compared with alternative management methods for atrial flutter or fibrillation. (See Supraventricular Tachyarrhythmias under Uses.)

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ibutilide
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What is the most important information I should know about ibutilide?

If possible, tell your doctor if you have taken a heart rhythm medication within the past 4 hours before receiving ibutilide.

In an emergency situation, it may not be possible to tell your caregivers that you are pregnant or breast-feeding before you are treated with ibutilide. However, make sure any doctor caring for your pregnancy or your baby knows that you have received the medication.

In some cases, your heart rhythm problem can occur again or get worse even after you are treated with ibutilide. This may be more likely if you have other problems such as congestive heart failure. However, every effort will be made to quickly treat any additional heart rhythm problems you may have.

During your treatment with ibutilide, you will be watched closely with heart monitoring equipment so that any further problems can be treated quickly. Cardiac emergency equipment will also be kept nearby in case it is needed to treat you.

Heart monitoring may continue for several hours after you have stopped receiving ibutilide.

What is ibutilide?

Ibutilide is an anti-arrhythmic heart medication that corrects certain conditions of irregular heart rhythm.

Ibutilide is used to treat atrial fibrillation or atrial flutter. If not corrected, these heart rhythm disorders can lead to heart failure or stroke if not corrected.

Ibutilide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my health care provider before receiving ibutilide?

You should not receive this medication if you are allergic to ibutilide.

Tell your doctor about any heart rhythm medications you are taking.

In some cases, your heart rhythm problem can occur again or get worse even after you are treated with ibutilide. This may be more likely if you have other problems such as congestive heart failure. However, every effort will be made to quickly treat any additional heart rhythm problems you may have.

FDA pregnancy category C. This medication may be harmful to an unborn baby and is not recommended in pregnant women unless clearly needed. It is not known whether ibutilide passes into breast milk or if it could harm a nursing baby.

In an emergency situation, it may not be possible to tell your caregivers that you are pregnant or breast-feeding before you are treated with ibutilide. However, make sure any doctor caring for your pregnancy or your baby knows that you have received the medication.

How is ibutilide given?

Ibutilide is given as an injection through a needle placed into a vein. You will receive this injection in a hospital or emergency setting.

During your treatment with ibutilide, you will be watched closely with heart monitoring equipment so that any further problems can be treated quickly. Cardiac emergency equipment will also be kept nearby in case it is needed to treat you.

Your heart rate will be constantly monitored through electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of the heart. This will help your doctor determine how long to treat you with ibutilide.

Heart monitoring may continue for several hours after you have stopped receiving ibutilide.

What happens if I miss a dose?

Since ibutilide is given as needed by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose?

Tell your caregivers right away if you think you have received too much of this medicine.

Overdose symptoms may include drowsiness, gasping for breath, or seizure (convulsions).

What should I avoid after receiving ibutilide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you are treated with ibutilide.

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