• bronchospasm (wheezing, chest tightness, trouble breathing);

• fast or uneven heart beats, restless feeling, tremor;

• fever, chills, stabbing chest pain, cough with yellow or green mucus;

• blurred vision, eye pain, or seeing halos around lights;

• white patches or sores inside your mouth or on your lips; or

• worsening asthma symptoms.

Less serious side effects include:

• headache, dizziness;

• nausea, vomiting, diarrhea;

• dryness in your mouth, nose, or throat;

• stuffy nose, sinus pain, cough, sore throat; or

• hoarseness or deepened voice.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect this medication?

Before using fluticasone and salmeterol inhalation, tell your doctor if you are using any of the following drugs:

• amiodarone (Cordarone);

• a diuretic or "water pill";

• HIV medicines such as atazanavir (Reyataz), ritonavir (Norvir), indinavir (Crixivan), nelfinavir (Viracept), or saquinavir (Invirase);

• an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam);

• an antidepressant such as amitriptyline (Elavil), desipramine (Norpramin), fluoxetine (Prozac), nefazodone, or imipramine (Tofranil);

• antibiotics such as ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), or telithromycin (Ketek); or

• a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), timolol (Blocadren), and others.

This list is not complete and there may be other drugs that can interact with fluticasone and salmeterol inhalation. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about fluticasone and salmeterol inhalation.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.