Drug Notebook

FDA Alerts

  • Possible serious and/or life-threatening cerebral and/or peripheral ischemia when administered concomitantly with potent CYP3A4 inhibitors (see Interactions); concomitant use contraindicated.

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ergotamine
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(er GOH ta meen)

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an ergotamine overdose include nausea, vomiting, weakness, muscle pain, numbness in your fingers or toes, gangrene, itching, confusion, drowsiness, convulsions, and possibly death.

What should I avoid while taking ergotamine?

Do not take more than three tablets in a 24-hour period. Do not take more than five tablets in 7 days. If your symptoms are not being adequately treated, talk to your doctor.

What are the possible side effects of ergotamine?

Stop taking ergotamine and seek emergency medical attention or contact your doctor immediately if you experience.
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • chest pain;

  • numbness or tingling in the fingers or toes;

  • muscle pain in the arms or legs;

  • leg weakness;

  • changes in heart rate;

  • swelling; or

  • itching.

Other, less serious side effects may also occur. Continue to take ergotamine and talk to your doctor if you experience nausea or vomiting.

Ergotamine may be habit forming when used for long periods of time. Larger doses may be needed for headache relief, and withdrawal effects may occur when treatment with ergotamine is stopped.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect ergotamine?

Some medications may increase the risk of dangerously decreased blood flow to the brain, heart, or extremities when taken with ergotamine. In rare but severe cases, gangrene or other serious problems can result. The following drugs should not be taken with ergotamine or should be used only under the close supervision of a doctor:

Drugs other than those listed here may also interact with ergotamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

Your pharmacist has more information about ergotamine written for health professionals that you may read.

What does my medication look like?

Ergotamine is available with a prescription under the brand names Ergostat and Ergomar. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Ergostat 2 mg--sublingual, orange tablets

  • Ergomar 2 mg-round, green tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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