Tell your doctor if you have an illness that involves diarrhea or vomiting lasting more than a few hours. Prolonged diarrhea or vomiting can lower your potassium levels, making it dangerous for you to use dofetilide.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your heart and kidney function will also need to be tested. Do not miss any scheduled visits to your doctor.

Dofetilide may be available only from a hospital or specialty pharmacy.

What is dofetilide?

Dofetilide is a heart rhythm medication, also called an antiarrhythmic.

Dofetilide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter.

Dofetilide may also be used for other purposes not listed in this medication guide.

What should I discuss with my health care provider before taking dofetilide?

• severe kidney disease; or

• a history of "Long QT syndrome."

There are certain drugs that should not be used together with dofetilide. Tell your doctor knows if you take any of the following medications:

• verapamil (Covera, Calan, Isoptin, Verelan);

• cimetidine (Tagamet);

• ketoconazole (Nizoral);

• prochlorperazine (Compazine);

• megestrol (Megace); or

• trimethoprim (Proloprim, Trimpex, Bactrim, Cotrim, Septra).

Before using dofetilide, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take dofetilide. Your doctor will tell you if any of your medication doses need to be changed.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether dofetilide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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