• unexplained weakness with vomiting and confusion or fainting;

• easy bruising or bleeding, blood in your urine;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• fever, chills, body aches, flu symptoms;

• urinating less than usual;

• hallucinations (seeing things that aren't there);

• extreme drowsiness, lack of coordination; or

• double vision or back-and-forth movements of the eyes.

Less serious side effects may include:

• mild drowsiness or weakness;

• diarrhea, constipation, upset stomach;

• depression, anxiety, or other emotional changes;

• changes in your menstrual periods;

• enlarged breasts;

• tremor (shaking);

• hair loss;

• weight changes;

• vision changes; or

• unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect divalproex sodium?

Before taking divalproex sodium, tell your doctor if you are using any of the following drugs:

• topiramate (Topamax);

• tolbutamide (Orinase);

• a blood thinner such as warfarin (Coumadin);

• aspirin or acetaminophen (Tylenol);

• zidovudine (Retrovir);

• clozapine (Clozaril, FazaClo);

• diazepam (Valium);

• meropenem (Merrem);

• rifampin (Rifadin, Rimactane, Rifater); or

• ethosuximide (Zarontin).

This list is not complete and there may be other drugs that can interact with divalproex sodium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about divalproex sodium.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.