Special Alerts:
[Posted 12/04/2007] FDA notified healthcare professionals and patients of the Agency's request that manufacturers update the prescribing information for desmopressin to include important new safety information about severe hyponatremia and seizures. Certain patients, including children treated with the intranasal formulation of the drug for primary nocturnal enuresis (PNE), are at risk for developing severe hyponatremia that can result in seizures and death. As such, desmopressin intranasal formulations are no longer indicated for the treatment of primary nocturnal enuresis and should not be used in hyponatremic patients or patients with a history of hyponatremia. PNE treatment with desmopressin tablets should be interrupted during acute illnesses that may lead to fluid and/or electrolyte imbalance. All desmopressin formulations should be used cautiously in patients at risk for water intoxication with hyponatremia. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2007/safety07.htm#Desmopressin and http://www.fda.gov/cder/drug/InfoSheets/HCP/desmopressinHCP.htm.
Fluid restriction is especially important in children and older adults taking desmopressin. Follow your doctor's instructions about the type and amount of liquids you should drink.
You should not use this medication if you have severe kidney disease or if you have ever had hyponatremia (low sodium levels in your body).Before taking desmopressin, tell your doctor if you have heart disease, coronary artery disease, congestive heart failure, kidney disease, cystic fibrosis, high or low blood pressure, an electrolyte imbalance, or a psychological disorder that causes extreme or unusual thirst.
To be sure desmopressin is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with this medication. Do not miss any scheduled appointments.
Desmopressin is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water.
Desmopressin is used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma.
Desmopressin may also be used for other purposes not listed in this medication guide.
severe kidney disease; or
if you have ever had hyponatremia (low sodium levels in your body).
Before taking desmopressin, tell your doctor if you are allergic to any medications, or if you have:
heart disease, coronary artery disease;
congestive heart failure;
kidney disease;
cystic fibrosis;
high or low blood pressure;
an electrolyte imbalance; or
a psychologic disorder that causes extreme or unusual thirst.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take desmopressin.
FDA pregnancy category B. This medication is not expected to harm an unborn baby. Do not use desmopressin without telling your doctor if you are pregnant. It is not known whether desmopressin passes into breast milk, or if it could harm a nursing baby. Do not use desmopressin without telling your doctor if you are breast-feeding a baby.Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
It is very important to reduce your intake of water and other fluids while you are taking desmopressin. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.Fluid restriction is especially important in children and older adults taking desmopressin. Follow your doctor's instructions about the type and amount of liquids you should drink.
If you are switching from desmopressin nasal spray to desmopressin tablets, wait at least 24 hours after your last nasal dose before you take your first tablet.To be sure this medication is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with desmopressin. Do not miss any scheduled appointments.
Store the tablets at room temperature away from moisture, light, and heat.Related Learning Centers |
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