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What is the most important information I should know about danaparoid?

There is a risk of bleeding in the spinal or epidural space, possibly resulting in paralysis, when danaparoid is used along with spinal or epidural anesthesia or spinal puncture. This risk may be increased by the use of indwelling epidural catheters or by the concomitant use of drugs that affect blood clotting.

Do not inject this medication intramuscularly (into the muscle) or intravenously (into the vein). Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), or any other nonsteroidal anti-inflammatory medication without first talking to your doctor. These medicines may lead to bleeding when taken with danaparoid. Ask your pharmacist or doctor before taking any prescription or over-the-counter medication.

What is danaparoid?

Danaparoid is an anticoagulant (blood thinner). Danaparoid prevents the formation of blood clots.

Danaparoid is used to prevent blood clot formation following hip replacement surgery.

Danaparoid may also be used for purposes other than those listed in this medication guide.

Who should not use danaparoid?

You should not use danaparoid if you

• have a very low level of platelets in your blood,

• have uncontrolled active bleeding,

• have an allergy to pork products, or

• cannot have accurate blood testing done prior to and during dosing.

Before using danaparoid, tell your doctor if you

• have bacterial endocarditis,

• have high blood pressure that is not being controlled,

• need to have surgery or another invasive procedure,

• have hemophilia or another blood disorder,

• have a stomach ulcer,

• have liver disease, or

• have kidney disease.

You may not be able to use danaparoid, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.

Danaparoid (Normiflo) is in the FDA pregnancy category B. This means that it is not likely to harm an unborn baby. Do not use danaparoid without first talking to your doctor if you are pregnant. It is not known whether danaparoid passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use danaparoid?

Use danaparoid exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Danaparoid must be used as a subcutaneous (under the skin) injection.

Do not inject this medication intramuscularly (into a muscle) or intravenously (into a vein).

Your doctor or nurse will give you detailed instructions on how to inject danaparoid. It should be injected into the fat of the stomach. Follow your doctor's instructions.

Sit or lie down before receiving an injection. Lift a fold of skin and insert the needle completely into the fold at a 45 to 90 degree angle. Continue to pinch the skin until the injection is complete. To lessen bruising, do not rub the area after injecting the medication.

Do not use any medication that is discolored or that has particles in it.

Do not stop using this medication without first talking to your doctor. Store danaparoid at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and use only your next regularly scheduled dose. Do not use a double dose of this medication.

Notify your doctor if you miss a dose of danaparoid.