Drug Notebook

FDA Alerts

    Experience of Supervising Clinician
  • Conventional cytarabine: Use only under supervision of qualified clinicians experienced in therapy with antineoplastic agents. Consider possible benefits vs known risks of cytarabine treatment.
  • Liposomal cytarabine: Use only under supervision of qualified clinicians experienced in intrathecal therapy with antineoplastic agents; adequate diagnostic and treatment facilities must be readily available for management of complications.
    Induction Therapy with Conventional Cytarabine
  • Patients should be treated in a facility with laboratory and supportive resources sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity.
  • Risk of serious adverse effects, including myelosuppression with leukopenia, thrombocytopenia, and anemia. Less serious adverse effects include nausea, vomiting, diarrhea, abdominal pain, oral ulceration, and hepatic dysfunction. (See Cautions.)
    Chemical Arachnoiditis with Intrathecal Liposomal Cytarabine
  • Chemical arachnoiditis, a syndrome manifested principally by nausea, vomiting, headache, and fever, commonly occurs. If left untreated, may be fatal. (See Chemical Arachnoiditis Related to Liposomal Cytarabine under Cautions.)
  • Administer dexamethasone to ameliorate symptoms and reduce incidence. (See Liposomal Cytarabine under Dosage and Administration.)

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What is the most important information I should know about cytarabine?

Do not receive this medication without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before receiving cytarabine, tell your doctor if you are allergic to any drugs, or if you have a breathing disorder such as asthma, or a history of stomach ulcer or bleeding.

Cytarabine can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with cytarabine. The live vaccine may not work as well during this time, and may not fully protect you from disease.

What is cytarabine?

Cytarabine is a cancer medication. Cytarabine interferes with the growth of cancer cells and slows their growth and spread in the body.

Cytarabine is used to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat leukemia associated with meningitis.

Cytarabine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving cytarabine?

You should not use this medication if you are allergic to cytarabine.

Before receiving cytarabine, tell your doctor if you are allergic to any drugs, or if you have:

  • asthma or other breathing disorder; or

  • a history of stomach ulcer or bleeding.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use cytarabine.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not receive cytarabine without telling your doctor if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. It is not known whether cytarabine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is cytarabine given?

Cytarabine is given as an injection through a needle placed into a vein, under the skin, or into the space around the spinal cord. You will receive this injection in a clinic or hospital setting.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Cytarabine can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What happens if I miss a dose?

Contact your doctor for instructions if you miss an appointment for your cytarabine injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include extreme drowsiness, or changes in personality or behavior.

What should I avoid while receiving cytarabine?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with cytarabine. The live vaccine may not work as well during this time, and may not fully protect you from disease.
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