• Basic Info
• Top Questions
• Clinical Info
• Interactions

What are the possible side effects of cyclophosphamide?

• an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);

• blood in the urine;

• black or tarry stools;

• painful or difficult urination;

• signs of infection such as fever; chills, or sore throat;

• jaundice (yellowing of the skin or eyes);

• lower back or side pain;

• chest pain, difficulty breathing, or swelling;

• unusual bleeding or bruising; or

• changes in bone marrow function (detected by blood tests).

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience

• nausea, vomiting, or decreased appetite;

• mouth sores;

• abdominal pain;

• diarrhea;

• temporary hair loss;

• temporary or permanent sterility;

• rash;

• changes in skin color; or

• changes in nails.

In some cases, secondary cancers have been reported to occur during and following treatment with cyclophosphamide. Talk to your doctor about the risks and benefits of this medication.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect cyclophosphamide?

Before taking cyclophosphamide, tell your doctor if you are taking any other medicines, especially any of the following:

• phenobarbital (Luminal, Solfoton);

• allopurinol (Zyloprim);

• digoxin (Lanoxin);

• warfarin (Coumadin);

• a thiazide diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others; or

• another chemotherapy medicine.

You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Other drugs may interact with cyclophosphamide. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with cyclophosphamide.

Where can I get more information?

Your pharmacist has additional information about cyclophosphamide written for health professionals that you may read.

What does my medication look like?

Cyclophosphamide is available with a prescription under the brand names Cytoxan and Neosar. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Cytoxan 25 mg-round, white tablets with blue flecks

• Cytoxan 50 mg-round, white tablets with blue flecks

• Cytoxan Lyophilized 100 mg -vial for injection

• Cytoxan Lyophilized 200 mg -vial for injection

• Cytoxan Lyophilized 500 mg -vial for injection

• Cytoxan Lyophilized 1gm -vial for injection

• Cytoxan Lyophilized 2 gm -vial for injection

• Neosar 100 mg -vial for injection

• Neosar 200 mg -vial for injection

• Neosar 500 mg -vial for injection

• Neosar 1gm -vial for injection

• Neosar 2 gm -vial for injection

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.