• feeling short of breath, even at night or with mild exertion;

• swelling in your hands or feet;

• fever, weakness, sore throat, stiff muscles, confusion, sweating, fast or uneven heartbeats;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• chest pain, sudden cough, wheezing, rapid breathing, fast heart rate, pain or swelling in one or both legs;

• white patches or sores inside your mouth or on your lips;

• nausea, vomiting, loss of appetite, and jaundice (yellowing of your skin or eyes); or

• seizure (black-out or convulsions).

Less serious side effects may include:

• constipation;

• drooling, especially at night;

• increased sweating;

• drowsiness, dizziness, spinning sensation;

• sleep problems or nightmares; or

• weight gain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect clozapine?

Before taking clozapine, tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• citalopram (Celexa);

• lithium (Eskalith, Lithobid);

• rifampin (Rifadin, Rimactane);

• blood pressure medications;

• heart rhythm medications such as propafenone (Rythmol) or flecaininde (Tambocor);

• seizure medicine such as phenytoin (Dilantin) or carbamazepine (Tegretol);

• antibiotics such as ciprofloxacin (Cipro) or erythromycin (E-Mycin, E.E.S, Ery-Tab);

• atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), scopolamine (Transderm-Scop); or

• diazepam (Valium) or similar medicines such as alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), and others.

This list is not complete and there may be other drugs that can interact with clozapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about clozapine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.