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What is the most important information I should know about cisapride?

Do not take cisapride if you have heart disease or hardening of the arteries; heart failure; an irregular heartbeat or a history of irregular heartbeats; a history of prolonged QT intervals; a family history of congenital long QT syndrome; a slow heart rate that is considered a medical condition; a structural heart defect; heart block or other conduction disturbances; severe dehydration (loss of water), vomiting, malnutrition, an eating disorder; or kidney failure. These conditions may increase the risk of irregular heartbeats, heart attack, and death while taking cisapride. Do not take cisapride with any of the following drugs: antibiotics such as clarithromycin (Biaxin), erythromycin (Ery-Tab, E.E.S., E-Mycin, others), troleandomycin (TAO), and sparfloxacin (Zagam); antidepressants such as amitriptyline (Elavil), maprotiline (Ludiomil), and nefazodone (Serzone); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); phenothiazines such as prochlorperazine (Compazine, others) and promethazine (Phenergan, others); antihistamines such as astemizole (Hismanal); blood pressure medications such as bepridil (Vascor); heart medications such as procainamide (Procan SR, Procanbid, Pronestyl) and quinidine (Quinidex, Quinaglute); and HIV medications such as indinavir (Crixivan) and ritonavir (Norvir). Taken with any of these drugs, cisapride may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart problems. Talk to your doctor or pharmacist before taking any other medications. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking cisapride. Use other medications cautiously during treatment with cisapride to avoid harming yourself or others. Excessive drowsiness may result if benzodiazepines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), and temazepam (Restoril) are taken during treatment with cisapride. Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products may increase amount of cisapride available in your body, which could lead to dangerous side effects.

What is cisapride?

Cisapride increases the rate at which your esophagus, stomach, and intestines move during digestion. It also increases the rate at which your stomach empties into your intestines and increases the strength of your lower esophageal sphincter (the muscle between your stomach and your esophagus).

Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn.

Cisapride may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking cisapride?

Do not take cisapride if you

• have bleeding, an injury, or an obstruction in your stomach;

• have heart disease or hardening of the arteries;

• have heart failure;

• have an irregular heartbeat or a history of irregular heartbeats;

• have a history of prolonged QT intervals;

• have a family history of congenital long QT syndrome;

• have a slow heart rate that is considered a medical condition;

• have a structural heart defect;

• have heart block or other conduction disturbances;

• have severe dehydration (loss of water), vomiting, malnutrition, an eating disorder;

• have kidney failure; or

• have severe lung problems or advanced cancer.

The conditions listed above may increase the risk of dangerous side effects including irregular heartbeats, heart attack, and death while taking cisapride.

Do not take cisapride with any of the following drugs:

• antibiotics such as clarithromycin (Biaxin), erythromycin (Ery-Tab, E.E.S., E-Mycin, others), troleandomycin (TAO), and sparfloxacin (Zagam);

• antidepressants such as amitriptyline (Elavil), maprotiline (Ludiomil), and nefazodone (Serzone);

• antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral);

• phenothiazines such as prochlorperazine (Compazine, others) and promethazine (Phenergan, others);

• antihistamines such as astemizole (Hismanal); blood pressure medications such as bepridil (Vascor);

• heart medications such as procainamide (Procan SR, Procanbid, Pronestyl) and quinidine (Quinidex, Quinaglute); or

• HIV medications such as indinavir (Crixivan) and ritonavir (Norvir).

Taken with any of the drugs listed above, cisapride may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart problems. Talk to your doctor or pharmacist before taking any other medications.

Before taking cisapride, tell your doctor if you have kidney or liver disease. You may not be able to take cisapride, or you may require a lower dose or special monitoring during treatment. Cisapride is in the FDA pregnancy category C. This means that it is not known whether cisapride will harm an unborn baby. Do not take cisapride without first talking to your doctor if you are pregnant. Cisapride passes into breast milk. It is not known whether cisapride will harm a nursing infant. Do not take cisapride without first talking to your doctor if you are breast-feeding a baby.