Drug Notebook

FDA Alerts

  • May severely suppress bone marrow function. (See Hematologic Effects under Cautions.)
  • Known carcinogen. (See Carcinogenicity under Cautions.)
  • May cause fetal harm. (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
  • May cause male or female infertility. (See Fertility under Cautions.)

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chlorambucil
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(klor AM byoo sil)

What is the most important information I should know about chlorambucil?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Treatment with chlorambucil may increase your risk of developing other forms of cancer. This medication can also affect fertility (your ability to have children), whether you are a man or a woman. Talk to your doctor about your specific risks when using chlorambucil.

Chlorambucil can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Do not receive a "live" vaccine while you are being treated with chlorambucil.

Stop using chlorambucil and call your doctor at once if you have a seizure, red or peeling skin rash, severe nausea or stomach pain, jaundice (yellowing of your skin or eyes), any unusual mass or lump, fever, chills, sore throat, cough, flu-like symptoms, pale skin, easy bruising or bleeding, unusual weakness, white patches or sores inside your mouth or on your lips, or missed menstrual periods.

What is chlorambucil?

Chlorambucil is a cancer medication that interferes with cancer cells and slows their growth and spread in the body.

Chlorambucil is used to treat several types of cancer, including Hodgkin's disease and certain types of leukemia or lymphoma.

Chlorambucil may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorambucil?

Do not use this medication if you are allergic to chlorambucil, or if you have received this medication in the past without successful treatment of your condition.

Before using chlorambucil, tell your doctor if you are allergic to any drugs, or if you have received radiation treatment within the past 4 weeks. You may not be able to use chlorambucil, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use chlorambucil without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

This medication can affect fertility (your ability to have children), whether you are a man or a woman.

It is not known whether chlorambucil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Treatment with chlorambucil may increase your risk of developing other forms of cancer. Talk to your doctor about your specific risk.

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