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captopril-hydrochlorothiazide
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(hye droe klor oh THY a zide and KAP toe pril)

What is the most important information I should know about hydrochlorothiazide and captopril?

Do not use this medication if you are unable to urinate.

You should not use this medication if you are allergic to other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and captopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, congestive heart failure, asthma or allergies, gout, lupus, diabetes, or an allergy to sulfa drugs.

Captopril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and captopril without telling your doctor if you are pregnant or planning a pregnancy. Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and captopril, unless your doctor has told you to.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

What is hydrochlorothiazide and captopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and captopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and captopril?

Do not use this medication if you are allergic to hydrochlorothiazide or captopril, or if you have:
  • a history of asthma or allergies; or

  • if you are unable to urinate.

You should not use this medication if you are allergic to other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and captopril, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • congestive heart failure;

  • gout;

  • lupus;

  • diabetes; or

  • an allergy to sulfa drugs.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take hydrochlorothiazide and captopril.

FDA pregnancy category D. Do not use this medication without telling your doctor if you are pregnant or planning a pregnancy. Captopril could cause birth defects in the baby if you take the medication during pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. Hydrochlorothiazide and captopril can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
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