Drug Notebook

FDA Alerts

    Alterations in Anticoagulant Effects
  • Altered coagulation parameters (e.g., increased PT, increased INR) and/or bleeding, sometimes fatal, reported in patients, with or without liver metastases, receiving capecitabine concomitantly with coumarin-derivative anticoagulants. Generally occurs within several days to months following initiation of therapy, but has been reported within 1 month following discontinuance of therapy. (See Coagulopathy under Cautions and also see Specific Drugs under Interactions.)
  • Age >60 years and diagnosis of cancer may independently increase risk of coagulopathy.
  • Monitor anticoagulant response (PT or INR) frequently in patients receiving concomitant capecitabine and oral coumarin-derivative therapy; adjust anticoagulant dosage accordingly.

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capecitabine
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(cah peh SIGH tah bean)

What other drugs will affect capecitabine?

Talk to your doctor if you are taking the blood thinner warfarin (Coumadin). In some cases, severe bleeding and death have resulted when these medications were taken together, or when treatment with warfarin (Coumadin) was started in the month following treatment with capecitabine. If treatment with both medications is determined by your doctor to be necessary, special monitoring will be required. Do not take any of the following medicines during treatment with capecitabine without first talking to your doctor:
  • phenytoin (Dilantin);

  • leucovorin (Wellcovorin); or

  • folic acid.

You may not be able to take capecitabine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with capecitabine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

Your pharmacist has additional information about capecitabine written for health professionals that you may read.

What does my medication look like?

Capecitabine is available with a prescription under the brand name Xeloda. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Xeloda 150 mg--oblong light peach-colored tablets

  • Xeloda 500 mg-oblong peach-colored tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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