• black, bloody, or tarry stools;

• blood in your urine;

• coughing up blood or vomit that looks like coffee grounds;

• pale skin, easy brusing or bleeding;

• wheezing, chest tightness, trouble breathing;

• decreased hearing or ringing in the ears;

• seizure (convulsions); or

• dizziness, confusion, or hallucinations.

Continue using aspirin and talk with your doctor if you have any of these less serious side effects:

• nausea, vomiting, stomach pain; or

• rectal irritation.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect aspirin rectal?

Before using aspirin rectal, tell your doctor if you are using any of the following drugs:

• alprostadil (Caverject, Edex);

• epitifibatide (Integrilin);

• tirofiban (Aggrastat);

• probenecid (Benemid);

• divalproex (Depakote) or valproic acid (Depacon, Depakene);

• an antacid or laxative;

• a blood thinner such as heparin or warfarin (Coumadin);

• cancer medicine such as abciximab (Reopro), methotrexate (Folex, Rheumatrex, Folex), plicamycin (Mithracin);

• insulin or diabetes medicine you take by mouth;

• an antibiotic such as cefemandole (Maxipime), cefoperazone (Cefobid), cefotetan (Cefotan), ciprofloxacin (Cipro), demeclocycline (Declomycin), doxycycline (Doryx, Periostat, Vibramycin), enoxacin (Penetrex), itraconazole (Sporanox), ketoconazole (Nizoral), lomefloxacin (Maxaquin), mezlocillin (Mezlin), minocycline (Dynacin, Minocin), norfloxacin (Noroxin), ofloxacin (Floxin), piperacillin (Pipracil), tetracycline (Broadspec, Panmycin, Sumycin), ticarcillin (Ticar), vancomycin (Vancocin);

• medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), and urokinase (Abbokinase);

• salicylates such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal; or

• NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene).

If you are using any of these drugs, you may not be able to use aspirin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect aspirin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about aspirin rectal written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.