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What is the most important information I should know about ardeparin?

Ardeparin was withdrawn from the U.S. market in March of 2000.

There is a risk of bleeding in the spinal or epidural space, possibly resulting in paralysis, when ardeparin is used along with spinal or epidural anesthesia or spinal puncture. This risk may be increased by the use of indwelling epidural catheters or by the concomitant use of drugs that affect blood clotting.

Do not inject this medication intramuscularly (into the muscle) or intravenously (into the vein). Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), or any other nonsteroidal anti-inflammatory medication without first talking to your doctor. These medicines may lead to bleeding when taken with ardeparin. Ask your pharmacist or doctor before taking any prescription or over-the-counter medication.

What is ardeparin?

Ardeparin was withdrawn from the U.S. market in March of 2000.

Ardeparin is an anticoagulant (blood thinner). Ardeparin prevents the formation of blood clots.

Ardeparin is used to prevent blood clot formation following knee replacement surgery.

Ardeparin may also be used for purposes other than those listed in this medication guide.

Who should not use ardeparin?

Do not use this medication if you

• have a very low level of platelets in your blood,

• have uncontrolled active bleeding,

• have an allergy to pork products, or

• cannot have accurate blood testing done prior to and during dosing.

Before using ardeparin, tell your doctor if you

• have bacterial endocarditis,

• have high blood pressure that is not being controlled,

• need to have surgery or another invasive procedure,

• have hemophilia or another blood disorder,

• have a stomach ulcer,

• have eye problems due to diabetes or high blood pressure,

• have liver disease, or

• have kidney disease.

You may not be able to use ardeparin, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.

Ardeparin (Normiflo) is in the FDA pregnancy category C. This means that it is not known whether ardeparin will harm an unborn baby. Do not use ardeparin without first talking to your doctor if you are pregnant. It is also not known whether ardeparin passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.