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What is the most important information I should know about amoxicillin, clarithromycin, and lansoprazole?

You should not take this medication if you are allergic to amoxicillin (Amoxil, Trimox, Dispermox), clarithromycin (Biaxin), lansoprazole (Prevacid), or to certain other antibiotics.

While you are taking amoxicillin, clarithromycin, and lansoprazole, do not take any of the following medications: cisapride (Propulsid), ergotamine (Ergomar, Cafergot, Ercaf, Migergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), pimozide (Orap), astemizole (Hismanal), or terfenadine (Seldane, Seldane-D).

Tell your doctor if you have kidney or liver disease, or if you are allergic to any drugs (especially any antibiotics).

Amoxicillin can make birth control pills less effective, which may result in pregnancy. Before taking amoxicillin, clarithromycin, and lansoprazole, tell your doctor if you use birth control pills.

There are many other medicines that can interact with amoxicillin, clarithromycin, and lansoprazole. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

What is amoxicillin, clarithromycin, and lansoprazole?

Amoxicillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.

Clarithromycin is in a group of drugs called macrolide antibiotics. Clarithromycin fights bacteria in your body.

Lansoprazole decreases the amount of acid produced in the stomach.

The combination of amoxicillin, clarithromycin, and lansoprazole is used to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and lansoprazole may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amoxicillin, clarithromycin, and lansoprazole?

You should not take this medication if you are allergic to amoxicillin (Amoxil, Trimox, Dispermox), clarithromycin (Biaxin), lansoprazole (Prevacid), or to any of the following antibiotics:

• ampicillin (Omnipen, Principen);

• azithromycin (Zithromax);

• carbenicillin (Geocillin);

• dicloxacillin (Dycill, Dynapen);

• erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);

• oxacillin (Bactocill);

• penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others);

• telithromycin (Ketek); or

• troleandomycin (Tao).

Taking any of the following medicines together with amoxicillin, clarithromycin, and lansoprazole can cause a life-threatening side effect on your heart:

• cisapride (Propulsid);

• ergotamine (Ergomar, Cafergot, Ercaf, Migergot);

• dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate);

• pimozide (Orap);

• astemizole (Hismanal); or

• terfenadine (Seldane, Seldane-D).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before taking amoxicillin, clarithromycin, and lansoprazole, tell your doctor if you have:

• kidney disease;

• liver disease; or

• if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, or penicillins such as Principen, Geocillin, Dycill, Bactocil and others).

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Amoxicillin can make birth control pills less effective, which may result in pregnancy. Before taking amoxicillin, clarithromycin, and lansoprazole, tell your doctor if you use birth control pills. Amoxicillin, clarithromycin, and lansoprazole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.