Drug Notebook

FDA Alerts

  • Hyperkalemia (i.e., serum potassium concentrations >5.5 mEq/L) may occur with all potassium-sparing agents, including amiloride.
  • Hyperkalemia occurs in about 10% of patients not receiving a kaliuretic diuretic and more frequently in patients with renal impairment or diabetes (even without evidence of renal impairment) and in geriatric patients. In patients without the mentioned complications, incidence of hypercalcemia is reduced to 1–2% by concomitant use of amiloride with a thiazide diuretic.
  • Uncorrected hyperkalemia may be fatal; monitor serum potassium concentrations carefully, especially during initial therapy or dosage adjustments, and in patients with concurrent illness that may affect renal function.

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amiloride
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(a MIL o ride)

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an amiloride overdose may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.

What should I avoid while taking amiloride?

Avoid drinking alcohol, which can increase some of the side effects of amiloride. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What are the possible side effects of amiloride?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

Continue using amiloride and talk with your doctor if you have any of these less serious side effects:

  • headache;

  • mild nausea, loss of appetite;

  • gas, stomach pain; or

  • skin rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect amiloride?

Before taking this medication, tell your doctor if you are using any of the following drugs:

If you are using any of these drugs, you may not be able to use amiloride, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect amiloride. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has additional information about amiloride written for health professionals that you may read.

What does my medication look like?

Amiloride is available with a prescription under the brand name Midamor. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Midamor 5 mg--diamond-shaped, yellow, compressed tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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