Drug Notebook

FDA Alerts

    Administration Warnings
  • For IV use only.
  • Fatal if given intrathecally. (See Intrathecal Administration under Cautions.)
  • Extremely important to properly place IV needle or catheter before any vincristine is injected.
  • Leakage into surrounding tissues may cause considerable irritation.
  • Discontinue immediately if leakage occurs; administer remainder of the dose through another vein.
  • Local treatment of leakage area (e.g., with hyaluronidase injection, application of moderate heat) may help disperse vincristine and minimize discomfort and possibility of cellulitis.

    Limit to Qualified Personnel
  • For administration only by individuals experienced in the administration of vincristine.

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Many drugs may interact with vincristine. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with vincristine.

If you experience any of the following side effects from vincristine, contact your doctor:

  • an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • nerve problems (such as burning, pricking, or tingling; loss of reflexes, or difficulty walking);

  • little or no urine production, painful or difficult urination, or excessive urination;

  • constipation or abdominal cramps;

  • nausea, vomiting, or loss of appetite;

  • weight and muscle loss or wasting;

  • inflamation and sores on the lips or inside the mouth;

  • hearing problems;

  • vision problems;

  • jaw, throat, bone, back, or limb pain;

  • headache;

  • temporary hair loss; or

  • redness, burning, or irritation at the injection site.

Menstruation in women and sperm production in men may stop.

Other side effects have also been reported. Discuss with your doctor any side effect that occurs during treatment with vincristine.

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