• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking topiramate, tell your doctor if you are taking any of the following medicines:

• amitriptyline (Elavil, Etrafon);

• atropine (Donnatal, and others);

• benztropine (Cogentin);

• glycopyrrolate (Robinul);

• hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic);

• methscopolamine (Pamine) or scopolamine (Transderm-Scop);

• risperidone (Risperdal);

• bladder or urinary medications such as darifenacin (Enablex), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

• bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

• diabetes medicine you take by mouth, such as pioglitazone (Actos) or metformin (Actoplus Met, Avandamet, Glucophage, Fortamet);

• glaucoma medications such as acetazolamide (Diamox), methazolamide (Neptazane), or dichlorphenamide (Daranide);

• irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), propantheline (Pro-Banthine); or

• other seizure medications such as carbamazepine (Carbatrol, Tegretol), lamotrigine (Lamictal), phenytoin (Dilantin), or valproic acid (Depakote, Depakene).

This list is not complete and there may be other drugs that can interact with topiramate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Stop taking topiramate and call your doctor at once if you have any of these serious side effects:

• sudden vision loss, pain around or behind your eyes;

• dry mouth, increased thirst, confusion, drowsiness, decreased sweating, increased body temperature, and hot, dry skin,

• nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions); or

• severe pain in your side or lower back, painful or difficult urination.

Less serious side effects may include:

• slowed thinking, memory problems, trouble concentrating;

• problems with speech or balance;

• numbness or tingling;

• sleep problems (insomnia);

• tired feeling;

• headache, dizziness; or

• loss of appetite, weight loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.