• Home
• Learning Centers
• Diseases & Conditions
• Drugs
• Symptoms
• Videos
• Health Experts
• Tools
• Marketplace

• Basic Info
• Top Questions
• Clinical Info
• Interactions

Do not take ticlopidine without first talking to your doctor if you are taking any of the following medicines:

• aspirin;

• warfarin (Coumadin);

• heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), or enoxaparin (Lovenox);

• clopidogrel (Plavix);

• dipyridamole (Persantine); or

• a nonsteroidal anti-inflammatory medication such as ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Anaprox, Naprosyn, Aleve), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), diflunisal (Dolobid), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin).

The medicines listed above can cause bleeding, especially when taken with ticlopidine. This interaction could become dangerous.

Before taking ticlopidine, tell your doctor if you are taking

• antacids or cimetidine (Tagamet, Tagamet HB);

• digoxin (Lanoxin, Lanoxicaps);

• theophylline (Theo-Dur, Theochron, Theolair, others); or

• phenytoin (Dilantin).

You may require a dosage adjustment or special monitoring if you are taking any of the medications listed above.

Drugs other than those listed here may also interact with ticlopidine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking ticlopidine and seek emergency medical attention or notify your doctor immediately:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• bloody or black vomit or stools;

• unusual, prolonged, or severe bleeding or bruising;

• fever, chills, a sore throat, or other signs of infection;

• a rash (including pinpoint dots on the skin);

• yellow skin or eyes;

• abdominal pain;

• dark-yellow urine;

• light-colored stools;

• pale skin;

• weakness on a side of the body;

• severe headache, confusion, or dizziness;

• easy bruising; or

• a bleeding nose.

Other, less serious side effects may also occur. Continue to take ticlopidine and talk to your doctor if you experience

• upset stomach, nausea, or vomiting;

• ringing in the ears;

• diarrhea;

• dizziness; or

• itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.