• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking sulfasalazine, tell your doctor if you are using any of the following drugs:

• digoxin (digitalis, Lanoxin);

• folic acid (Folicin, FA-8); or

• vitamin or mineral supplements that contain folic acid.

This list is not complete and there may be other drugs that can interact with sulfasalazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using sulfasalazine and call your doctor at once if you have any of these serious side effects:

• fever, sore throat, or other flu symptoms;

• pale skin, easy bruising;

• dark urine, jaundice (yellowing of the skin or eyes);

• pain or burning when you urinate;

• urinating less than usual or not at all;

• the appearance of a whole tablet in your stool; or

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

• mild nausea, vomiting, diarrhea, upset stomach;

• loss of appetite;

• headache, ringing in your ears;

• dizziness, spinning sensation;

• white patches or sores inside your mouth or on your lips;

• sleep problems (insomnia); or

• mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.