Drug Notebook

FDA Alerts

  • Possible increase in asthma-related deaths in patients receiving long-acting β2-adrenergic bronchodilators, including salmeterol, in addition to usual asthma therapy.
  • Reserve use of long-acting β2-adrenergic agonists in patients with asthma for those whose disease is inadequately controlled with other anti-asthma therapy (e.g., low to medium dosage of inhaled corticosteroids) or whose disease severity warrants treatment with 2 maintenance therapies. (See Increased Risk of Asthma-related Death under Cautions.)

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salmeterol
(sal MEE ter all)

Before using salmeterol inhalation, tell your doctor if you are using any of the following drugs:

  • diuretics (water pills);

  • a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard), or pindolol (Visken);

  • antidepressants such as amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), or imipramine (Tofranil);

  • an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam);

  • caffeine, a diet medicine, or a decongestant; or

  • aminophylline (Truphylline), theophylline (Slo-Bid, Theobid, TheoDur), and others.

This list is not complete and there may be other drugs that can interact with salmeterol inhalation. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • chest pain, fast or pounding heartbeats, tremors, shaking, or restless feeling;

  • wheezing, choking, or other breathing problems after using this medication;

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or

  • worsening asthma symptoms.

Less serious side effects may include:

  • headache, dizziness, lightheadedness, or insomnia;

  • sweating;

  • nausea, vomiting, or diarrhea; or

  • dry mouth or throat irritation.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

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