• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• antacids (take antacids at least 2 hours before or 2 hours after taking a dose of prochlorperazine; otherwise they will decrease the effectiveness of your medication);

• alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; or seizure medications. (these drugs will increase the side of effects of prochlorperazine, especially drowsiness and dizziness);

• blood pressure medications such as propranolol (Inderal), methyldopa (Aldomet), and clonidine (Catapres) (these medicines may cause dizziness and fainting if used with prochlorperazine);

• anticoagulants such as warfarin (Coumadin) (these medicines may have decreased effects, which could lead to blood clotting); and

• phenytoin (Dilantin) (prochlorperazine may increase the effects of phenytoin and lead to side effects; you may need a lower dose of phenytoin).

Drugs other than those listed here may also interact with prochlorperazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If you experience any of the following serious side effects, stop taking prochlorperazine and seek emergency medical treatment:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• uncontrollable movements of the tongue, face, lips, arms, or legs;

• muscle spasms of the face or neck;

• severe restlessness or tremor;

• severe drowsiness or fainting; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take prochlorperazine and talk to your doctor if you experience

• decreased sweating;

• dry mouth and stuffy nose;

• constipation;

• blurred vision;

• mild restlessness, weakness, or tremor;

• difficult urination or dark urine;

• decreased sex drive;

• dizziness; or

• increased appetite.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.