• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before using procaine, talk to your doctor if you are taking any of the following medicines:

• warfarin (Coumadin);

• a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);

• mecamylamine (Inversine);

• guanadrel (Hylorel) or guanethidine (Ismelin);

• a medicine to treat high blood pressure; or

• a medicine to improve muscle strength or tone for conditions such as myasthenia gravis.

You may not be able to use procaine, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with procaine. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Stop using procaine and seek emergency medical attention or contact your doctor immediately if you experience any of the following rare but serious side effects:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• chest pain or slow or irregular heartbeats;

• dizziness or drowsiness;

• anxiety or restlessness;

• nausea or vomiting; or

• trembling, shaking, or seizures (convulsions).

Other less serious side effects such as numbness, tingling, or minor pain at or around the injection site are more likely to occur. Contact your healthcare provider if these effects seem excessive or prolonged.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.