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• Interactions

Many drugs can interact with probenecid. Below is just a partial list. Tell your doctor if you are using:

• lorazepam (Ativan);

• methotrexate (Rheumatrex, Trexall);

• rifampin (Rifadin, Rifamate, Rimactane);

• diabetes medication you take by mouth;

• an NSAID (nonsteroidal anti-inflammatory drug) such as ketoprofen (Orudis, Oruvail), indomethacin (Indocin), meclofenamate (Meclomen), or naproxen (Aleve, Anaprox, Naprosyn);

• salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others; or

• a sulfa drug such as Bactrim, Cotrim, Septra, SMX/TMP, and others.

This list is not complete and there may be other drugs that can interact with probenecid. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• worsening gout symptoms;

• severe pain in your side or lower back;

• blood in your urine;

• swelling, especially in your face, stomach, ankles, or feet; or

• pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Less serious side effects may include:

• urinating more than usual;

• mild nausea, vomiting, loss of appetite;

• headache, dizziness;

• sore gums;

• mild itching or skin rash;

• hair loss; or

• warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.