Before taking pegvisomant, tell your doctor if you are taking any of the following medicines:
insulin;
any medicine taken by mouth to treat diabetes such as
glyburide (Diabeta, Glynase, Micronase), glipizide (Glucotrol), glimepiride (Amaryl),
rosiglitazone (Avandia), pioglitazone (Actos), and others; or
a narcotic pain or cough medication such as codeine
(Tylenol #3, others), hydrocodone (Vicodin, Lorcet, others), oxycodone (Percocet, others),
morphine (MS Contin, MSIR, OxyContin, others), fentanyl (Duragesic, others), and others.
You may not be able to take pegvisomant, or you may require a dosage
adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with pegvisomant. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals,
and herbal products.
If you experience any of the following uncommon but serious side effects, stop taking
pegvisomant and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives); or
liver problems (may be detected by blood tests or symptoms
such as yellowing of the skin or eyes, vomiting, abdominal pain, unusual fatigue, loss of appetite,
itching, clay-colored stools, or dark urine).
Other, less serious side effects may be more likely to occur. Continue to
take pegvisomant and talk to your doctor if you experience
discomfort at the injection site;
"flu-like" symptoms
nausea or diarrhea;
dizziness; or
water retention or slight weight gain.
Side effects other than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially bothersome.
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